Effect of ionizing irradiation on normal lymphatic vessels and lymph nodes

Recent developments in morphology of lymphatic vessels and lymph nodes.

This paper reviews the morphology of lymphatics and lymphangiogenesis in vivo, microenvironments that promote lymphangiogenesis, and the structure and function of lymph nodes. Lymphatic capillaries consist of a single layer of lymphatic endothelial cells (LECs) and have valves, while collecting lymphatics are endowed with smooth muscle cells (SMCs) and valves besides a single layer of LECs. In ...

Effects of Ionizing Radiation on Normal and Tumor-Associated Lymphatic Vessels

Lymphatic vessels play a crucial role in both the pathophysiology of tumors and in the spread cancer cells to lymph nodes. The effects of radiation on these vessels, however, are largely unknown. Here, we seek to describe the effects of ionizing radiation on normal and tumor-associated lymphatic vessels in vitro and in vivo. Clonogenic assays were employed to study the radiation dose response o...

Further histological observations on popliteal lymph nodes after interruption of the afferent lymphatic vessels.

Lymphatic vessels afferent to the popliteal nodes in young adult rats and guinea pigs were interrupted at the lowest edge of the popliteal fossa, and regressive changes in the nodes occurring 4 to 16 or 18 weeks after surgery were re-examined histologically. In the rat, some popliteal nodes were drained by lymphatic channel(s) from the tail. After surgery, the popliteal nodes without lymphatic ...

The Lymphatic System and Lymph Nodes

Dynamic imaging of lymphatic vessels and lymph nodes using a bimodal nanoparticulate contrast agent.

BACKGROUND Evaluation of lymphedema and lymph node metastasis in humans has relied primarily on invasive or radioactive modalities. While noninvasive technologies such as magnetic resonance imaging (MRI) offer the potential for true three-dimensional imaging of lymphatic structures, invasive modalities, such as optical fluorescence microscopy, provide higher resolution and clearer delineation o...